Bioactive ingredients
Lentinan – The Immunomodulator
BRM (Biological Response Modifier)
Immunomodulatory – Regulation of the immune system
Antitumor – Inhibition of cancer cells
Antimetastatic – Prevention of metastasis
Antimicrobial – Combating pathogenic microorganisms
Antiviral – Inhibition of viral replication
Eritadenine – The Heart Protector
Cholesterol-lowering – Regulation of lipid metabolism
Antithrombotic – Prevention of blood clots
Antiatherogenic – Protection against atherosclerosis
Antiviral – Inhibition of viral activity
Antimicrobial – Broad-spectrum antimicrobial
L-Ergothioneine – The Super Antioxidant
Powerful antioxidant – protects cells from oxidative stress
Neuroprotective – Protection of nerve cells
Anti-inflammatory – Reduction of chronic inflammatory processes
Ergosterol – The Bone Strengthener
Bone and Cartilage Formation – Promoting Skeletal Health
Thioprolin – The Detoxifier
Nitrite remover – Binding harmful nitrogen compounds
Hepatoprotective – Protects liver cells
Antitumor – Cancer-inhibiting properties
Leninamycin A and B – The Antimicrobials
Antibacterial – Inhibition of bacterial pathogens
Antifungal – Treatment of fungal infections
KS-2 – The Interferon Stimulator
Alpha-mannan peptide from a mycelial alcohol extract
Interferon stimulation – promoting the body's own interferon production
Macrophage activation – stimulation to kill tumor cells
Polyphenols, tocopherols, and β-carotene – The antioxidants
Antioxidant – Protection against free radicals
Other antimicrobial compounds – The germ fighters
Erythritol, copalic acid, adenosine, carvacrol
Antimicrobial – Broad spectrum of activity against pathogens
Nutritional Profile – The Essential Nutrients Package
Macronutrients:
Moisture content: 78.5%
Protein: 13–33%
Fat: 0.94–7.2%
Carbohydrates: 21.7–47%
Polysaccharides: 6.35%
Dietary fiber: 6–38.3%
Ash: 3.5–6.5%
B-vitamin complex:
Thiamine (vitamin B1)
Riboflavin (Vitamin B2)
Niacin (vitamin B3)
Minerals:
Iron (Fe)
Calcium (Ca)
Zinc (Zn)
Magnesium (Mg)
Phosphorus (P)
Therapeutic Applications
Complementary Cancer Treatment – The Tumor Specialist
In Japan, lentinan is used to treat gastrointestinal cancer .
Improved Quality of Life – In Patients Receiving Combination Therapy
Reduction of side effects – Prevention of immune system damage prior to chemotherapy for breast cancer, significant reduction in cisplatin-induced kidney damage
Extended survival – For liver and stomach cancer, best results are achieved before chemotherapy
Reduction in recurrence rates – Lowering the frequency of cancer recurrence
Enhancement of the immune response – restoration of T-cell activity, induction of apoptosis and cytotoxic mechanisms
Clinical successes:
Better response to treatment in:
- Stomach, colon, liver, and esophageal cancer
- Lung, breast, ovarian, and cervical cancer
- Non-Hodgkin lymphomas
- Multiple types of cancer
- Bladder Cancer – Enhanced Inhibition of Cell Proliferation
Prostate Cancer – Conflicting Data: From a Lack of Positive Effects to Extended Survival in Metastatic Prostate Cancer
In vivo studies:
Cancer prevention in:
- Colon, liver, and bronchoalveolar cancer
- Melanomas
- HER2-positive breast, lung, and stomach cancer (in combination with chemotherapy)
In vitro studies:
Effective against:
- Triple-negative breast cancer
- Laryngeal, lung, prostate, and skin cancer
- leukemia cells
Immunostimulatory effect – The immune booster
General immunity – boosting immunity in healthy participants, especially those who need to improve their well-being
Increase in B-cell count – Increase in immune cells
Flu Vaccination Support – Fewer Cold Symptoms
Viral Infections – The Virus Fighter
HIV – In vitro antiviral activity, increase in T-cell count in AIDS patients
Chronic Hepatitis B and C – In vitro antiviral activity, improvement in liver function, HBeAg seroconversion in hepatitis B
Poliovirus Type 1 – Complete or partial inhibition of viral replication
Herpes simplex virus – Complete inhibition of HSV-1and HSV-2 replication in laboratory and animal models
Influenza – Antiviral activity in vitro and in vivo
Colds, Bronchitis – Therapeutic Support
Bacterial and Fungal Infections – The Germ Fighter
Candida albicans – Highest antifungal activity among various fungal species (in vitro and in vivo)
Bacterial infections – Antimicrobial activity against:
- Streptococcus pyogenes
- Staphylococcus aureus
- Escherichia coli
- Enterococcus faecalis
- Klebsiella pneumoniae
- Pseudomonas aeruginosa
Mycobacterium tuberculinum – Improvement through Lentinan Injections and Inhalations
Salmonella endotoxemia – Protection against septic shock caused by Salmonella lipopolysaccharides
Oral Health – Face Masks
Tooth Decay, Gingivitis, Periodontitis – Therapeutic Support
Antimicrobial effect in the oral cavity – effective against Fusobacterium nucleatum, minimal impact on healthy oral bacteria
Anti-plaque effect – reduction of bacterial plaque
Anti-gingivitis effect – Inhibits gum inflammation
Cardiovascular Diseases and Metabolic Syndrome – The Heart Protector
Preventive and therapeutic effects
Dyslipidemia, hypercholesterolemia – reduction of serum cholesterol, total cholesterol, and triglycerides
Atherosclerosis – Positive Results in Laboratory and Animal Studies
Thrombosis – In vitro antithrombotic effect
Cardiovascular risk factors:
- High blood pressure
- Type 2 diabetes mellitus
Weight Loss – Support for Weight Management
Gut Health – The Gut Care Specialist
Prebiotic Effects – In Vitro and In Vivo
Inflammatory Bowel Disease (IBD) – Improvements in Crohn’s disease and ulcerative colitis in vitro and in animal models
Osteoporosis – The Bone Strengthener
Anti-osteoporotic effects of syringin and vanillic acid:
Osteoclast inhibition – Reduction of bone resorption activity
Osteoblast mineralization – Promotion of bone formation
Osteocalcin production – Improving bone quality
Bone remodeling – Promising in vivo effects
Skin Health – The Skin Regenerator
Ergosterol (~10% of the content):
Skin cell regeneration – renewal of the skin's structure
Wound Healing – Accelerating the Healing Process
Skin tightening – Improving skin elasticity
Neurodegeneration – The Brain Protector
Improved microcirculation – promoting blood flow to the brain
Vasodilation
Preventing Loss of Elasticity – Protecting Blood Vessel Walls
Traditional Applications – The Time-Tested Range
General health promotion:
Improving Endurance – Boosting Physical Performance
Promoting Blood Circulation – Improving Circulation
Specific traditional indications:
Arthritis – Treatment for Joint Inflammation
Diabetes – Blood Sugar Regulation
Hypercholesterolemia – Lowering Cholesterol
Immune Deficiency – Boosting the Immune System
Traditional Chinese Medicine (TCM):
Viral Infections – Treatment of Hepatitis and HIV
Safety considerations
Shiitake Dermatitis – The Skin Reaction
Allergic skin reaction – caused by consumption of L. edodes
Sunlight-induced exacerbation – photosensitization
At-risk population – people living in shiitake-growing regions
Other allergic reactions:
Contact dermatitis – skin irritation among shiitake farmers
Asthma – Airway Reactions
Rhinitis – Inflammation of the nasal mucosa
Hypersensitivity Pneumonitis – Pneumonitis Caused by Hypersensitivity
Serious side effects – Rare complications
Anaphylaxis – Few cases following intravenous administration
Klinische Studien-Nebenwirkungen – Bei <10% der Patienten:
- Dermatitis (mild form)
- Nausea
- Gastrointestinal complaints
Lentinan-chemotherapy combination – 0.19% side effect rate:
Allergies – Hypersensitivity reactions
Skeletal muscle injuries – Muscle damage
Acute asthma – Severe airway reaction
Skin rash – Dermatological reactions
Shock – Circulatory collapse
Dizziness and Tremors – Neurological Symptoms
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