Hericium erinaceus – Lion’s Mane – Yamabushitake – Hou Tou Gu
NGF Stimulation – Promoting the Production of Nerve Growth Factor:
Neuronal protection – Prevention of neuronal death
Promotes growth – supports nerve cell growth and differentiation
Promotes synapse formation
Protects against oxidative stress – protects against free radicals
Anti-inflammatory – Reduction of microglial inflammation
Anti-aging – Protection against the aging process
Cognitive enhancer – improves cognitive function
Mycelium compounds – Can they cross the blood-brain barrier (BBB)?:
Erinacine A and B – Aromatic compounds
Erinacine A-C – The NGF Synthesizers:
Stimulates NGF synthesis – promotes the production of nerve growth factor
Synapse-forming – Supporting the formation of new synaptic connections
Anti-ischemic – Protection against circulatory disorders
Erinacine E – The Pain Reliever:
Opioid receptor-binding – binding to pain receptors
Analgesic – pain and cramp relief
Antibacterial – Effective against MRSA
Antidiabetic – Glucosidase-inhibiting effect
Fruit body compounds – substances that overcome BHS:
Hericenone A and B – Aromatic compounds
Hericenon B – The Thrombosis Inhibitor:
Antithrombotic – Anticoagulant effect
Hericenone C-H – The NGF activators:
Stimulates NGF synthesis – promotes nerve growth factor
Supports nerve cell membranes – Key components of nerve cell structure
NGF Induction – Stimulation of NGF Synthesis in Human Astrocytes
Antitumor – Cancer-fighting activity
Upregulation – Increased expression in the brain:
Neuroprotective – Protection against brain inflammation
Reduces oxidative stress – Reduces oxidative damage
Neuronal protection – protection against β-amyloid deposits and other stressors
Supports digestive health – supports the gastrointestinal tract
Antibacterial – Protection against pathogenic bacteria
Antioxidant – Cell protection against free radicals
Antioxidant – Powerful cell-protective properties
Macronutrients:
Moisture content: 10.68%
Protein: 9.55–31.7%
Fat: 0.78–4%
Carbohydrates: 17.6–26.72%
Polysaccharides: 5.81%
Dietary fiber: 30–47%
Ash: 5.27–9.8%
Vitamin complex: B1, B2, B3, D, provitamin D2
Essential minerals: Na, P, Fe, Ca, K, Mg
Alzheimer's disease (AD):
Cognitive improvements – Clinical studies in middle-aged adults, adults, and older adults:
Improving Short-Term Memory – Boosting Memory Performance
Visual Recognition – Improving Visual Perception
Cognitive and mental abilities – Enhancing mental performance
Daily Activities – Improving Daily Living Skills
Long-term effect – Lasting effect after discontinuation without side effects
Molecular mechanisms:
Reduction of Neuroinflammation – Reducing Brain Inflammation
Increased NGF Expression – Enhanced Nerve Growth Factor Production in Hippocampal Neurons
Increased acetylcholine – Elevated ACh and ChAT levels in serum and the hypothalamus
Combination therapy – Using T. versicolor to slow the progression of AD and maintain energy homeostasis
Multiple sclerosis:
Improved Myelination – Promoting the Formation of Nerve Sheaths in Animal Models
Neural Growth – Accelerated Support
Protection against oxidative stress – Prevention of neuronal death
Managing MS Relapses – Support for Recovery from Relapses
Parkinson's disease:
Promoting Neuron Survival – Protecting and Preserving Nerve Cells
Reducing oxidative stress – reducing cellular damage
Compensation for dopamine loss – Reduction of dopamine-related brain lesions
Polyneuropathies:
Diabetic Neuropathy – Specialized Care for Diabetes-Related Nerve Damage
Injuries to the nervous system:
Central nervous system injuries – Traumatic brain injuries:
Inflammation Reduction – Reducing inflammation in damaged brain regions
Reduction of oxidative stress – Protection against oxidative damage
Improvement in behavioral symptoms – reduction in anxiety and learning difficulties
Peripheral injuries:
Acceleration of Neuronal Regeneration – Potential Acceleration of Peripheral Nerve Healing
Anti-inflammatory properties – Strong anti-inflammatory effects
Improved immune response – Enhanced immune reaction at the site of injury
Reduction of Neuropathic Pain – Blocking the Transmission of Pain Signals
Cerebrovascular diseases:
Reduction of ischemic damage – Erinacin A and Hericenon B reduce ischemic damage
Thrombosis Prevention – Preventing Blood Clots
Anti-aging effects:
Improvement in Hearing Loss – Positive Effects on Age-Related Hearing Loss
Frailty Syndrome – Improving Age-Related Frailty in Animal Studies
Gastritis:
Inhibition of Helicobacter pylori – Complete in vitro and in vivo inhibition
Clinical Successes – Nearly 90% of patients tested negative for the antigen after treatment
Gastroesophageal reflux disease:
Heartburn Relief – Protection of the Esophageal Mucosa
Stomach and duodenal ulcers:
Cytoprotective – protective effect against gastric ulcers in vivo
Inflammatory bowel disease (IBD):
Crohn's disease and ulcerative colitis – Improvements in animal models:
Mucosal Healing – Repair of Damaged Stomach and Colon Mucosa
Swelling Reduction – Reducing Inflammation
Anti-inflammatory action – Suppression of inflammatory processes
Promoting Gut Bacteria – Growth of Beneficial Bacteria
Dysbiosis:
Regulation of the gut microbiota – increasing beneficial bacteria, reducing pathobionts
The Gut-Brain Axis – A Crucial Role in Mental Health and Cognitive Function
Leaky Gut Syndrome:
Strengthening the intestinal barrier – Restoring intestinal wall integrity
Constipation:
Promotes digestion – stimulates pancreatic secretion
MRSA:
Clinical Efficacy – Disappearance of MRSA in Patients Taking H. erinaceus Supplements
Bacterial infections:
Salmonella typhimurium – In vivo effect
E. coli, S. aureus, B. subtilis – In vitro activity
Viral infections:
HIV – Antiviral activity in vitro
Depression:
General Effects of Mushrooms – Eating Mushrooms May Reduce the Risk of Depression
Improvement in symptoms – reduction in symptoms of depression and anxiety:
Improved Concentration – Fewer Concentration Problems
Mood stabilization – reducing mood swings
Reducing Irritability – Less Frustration and Irritability
Relief from Heart Palpitations – Improvement in Cardiovascular Symptoms
Reducing Sleep Disorders – Improving Sleep Quality
Target groups – Effective for young women, menopausal women, overweight women, and overweight men
Long-lasting effects – effects persist after discontinuation
Successes in animal models – Antidepressant, anxiolytic, and anti-inflammatory effects
Anxiety and stress:
Improving recognition memory – Better handling of unfamiliar objects as a safeguard against anxiety and depression
Insomnia:
Reversal of Sleep Disorders – Improved Sleep in Mouse Models
Anxiety Reduction – Fewer Anxiety Attacks
Schizophrenia:
Symptom relief – Potential therapeutic effect
Menopause:
Relief from menopausal symptoms – improvement in depression, insomnia, anxiety attacks, and hot flashes (not yet confirmed by clinical studies)
Improved immune status:
Boosting the Immune System – Strengthening Immune Defenses
Inhibition of tumor growth – Activity against Sarcoma-180, gastric, esophageal, and skin cancer cells
Extension of survival time:
Multiple myeloma – In combination with A. blazei Murrill and G. frondosa, survival rates are 1.3 years longer
Reduction of side effects:
Chronic Pain – Relief of Cancer-Related Pain
Peripheral polyneuropathy – Improvement of chemotherapy-induced nerve damage
Chemotherapy Side Effects – General Symptom Relief
Anti-metastatic effect:
Esophageal and Colorectal Cancer – Inhibition of Metastasis
Gastrointestinal Cancer Specialist:
In vitro and in vivo activity:
Colon Cancer – Antitumor Effects in Clinical Trials
Stomach Cancer – Specific Efficacy
Liver Cell Cancer – Treating Hepatocellular Carcinoma
Lung Cancer – Effects in Mouse Models
Leukemia – In vitro activity
Lymphomas – Antitumor Properties
Breast Cancer – Antitumor Effect
Cervical Cancer – The Fight Against Cervical Cancer
Esophageal Cancer – Effects of Esophageal Carcinoma
High blood pressure:
Lowering Blood Pressure – Cardiovascular Regulation
Dyslipidemia:
Lipid-lowering – Regulation of lipid metabolism
Cholesterol-lowering – Improving cholesterol levels
Type 2 diabetes mellitus:
Blood sugar-lowering – Glucose regulation
Improving Diabetes – General Diabetes Management
Pain Relief for Neuropathy – Effective for Diabetic Nerve Damage
Atherosclerosis:
V ascular protection – Protection against atherosclerosis
Accelerated wound healing:
Scar Tissue Reduction – Reduced Scarring in Animal Studies
Atopic dermatitis:
Allergy-related skin conditions – Potential effects of food intolerances
Improved digestion:
Stomach Ulcers – Treatment of Ulcers
Duodenal Ulcers – Healing of Duodenal Ulcers
Acute and Chronic Gastritis – Treatment of Inflammation of the Stomach Lining
Neurasthenia – Treatment for Nervous Exhaustion
General Weakness – Combating Fatigue
Strength and Vitality – General Strengthening
Hypodynamia – Treatment for Low Energy
Memory Improvement – Boosting Your Ability to Remember
Promoting Concentration – Improving Attention
Cognitive Functions – Enhancing Mental Performance
Organ health:
Kidneys – Kidney Support
Heart – Heart Strengthening
Liver – Liver Protection
Lungs – Lung Support
Spleen – Strengthening the spleen
Insomnia – Promoting Sleep
Astringent – Tightening effect
Cancer – Tumor Treatment
Qi Deficiency – Restoring Energy Balance
References
Mycoverse Foundation
, Marktgass 11,
, 9490 Vaduz,
, Principality of Liechtenstein
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